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No, if you want to see the original undead apocalypse movie, this is where you need to go. Because without The Last Man on Earth, there would have been no Night of the Living Dead. Don't believe me? Just ask George Romero, he's said it himself on many on occasion. I've also always felt that this film version was greatly influenced by the Twilight Zone, yet presented in a more intense and brooding way that only a feature-length film can allow.
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Much more of the traditional vampire lore is maintained in this version, with Morgan staking the creatures through the heart, protecting himself with garlic, etc. And yet the seminal influence on zombie cinema is absolutely undeniable. We have the desperate guy seeking refuge in his boarded-up house. We have hordes of undead trying to get in and feast upon him. We have a worldwide epidemic. We have the fear of loved ones turning against you as they fall victim to the plague. It's all here. Just add a dash of Hitchcock's The Birds, and you have Romero's brainchild.
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The external location shooting in Rome adds to the film's feeling of realism--yes, Price's melodramatic hamminess is part of his charm, but it only makes for that much more of a jarring juxtaposition against the grim imagery of eerily empty city streets and fire pits filled with flaming corpses. If anything, it's a testament to Price's versatility that he fits in just as well in this scenario as in the classic Gothic visions of Roger Corman and the like.
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And like NOTLD, The Last Man on Earth has a stark, uncompromising downer of an ending. Much more so than either of the subsequent versions. It's well known that Matheson has never been satisfied with any filmed version of his book, including this one, and yet this one is probably the most faithful of the three. There might be some major deviations, but if you judge it without loyalty to the novel in mind, on its own merits, I think you'll find it to be a highly effective little horror flick.
The film rarely gets the credit it deserves for being one of the earliest "modern" horror movies, often being completely overshadowed by the much more flamboyant Omega Man of ten years later. But if anything, the shameless Hollywood-ization of the property that occurred with I Am Legend should draw even more attention to this overlooked 1960s gem. Seek it out--in fact, thanks to a lapsed copyright, you can actually watch it right now!