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Published by IDW in 2004, Wake the Dead is a modern re-telling of the Frankenstein story, and was a damn fine read in my opinion, nearly as good as the vampire saga for which he's better known. Niles himself talked to Comic Book Resources about the upcoming project today (to be scripted by Bram Stoker's Dracula's James V. Hart), and I urge all those interested to head there.
Now all I can hope for is that Robert Kirkman's mostly excellent The Walking Dead zombie comic gets the HBO series it so richly deserves...