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Prior to being homogenized by Harvard, the young Updike was particularly interested in science fiction, gravitating toward hard sci-fi writers like Isaac Asimov who displayed a solid knowledge of science, much like himself. Despite moving into the literary "mainstream" post-Harvard as a columnist for the New Yorker, Updike always retained a certain affection for the genre, incorporating it into several of his works, most notably the 1975 novella The Chaste Planet.
Updike's only foray into horror was a heavily diluted one, namely the 1984 horror/fantasy/comic novel The Witches of Eastwick. The tale of three witches who conjure up a mysterious demonic seducer was such a popular one that it has enjoyed several adaptations, most notably the 1987 film starring Jack Nicholson. It was also turned into two different TV movies and a 2000 stage musical, and a new ongoing series based on the novel is set to premiere on ABC in the fall.